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Research demonstrates that BPC-157 upregulates vascular endothelial growth factor receptor-2 (VEGFR2) at both mRNA and protein levels in endothelial cells without increasing VEGF-A itself, instead sensitizing cells to existing VEGF signaling while simultaneously activating the Src-Caveolin-1-endothelial nitric oxide synthase (eNOS) pathway

The preclinical numbers stand out: ~5% total body weight reduction in just 11 days, with 35% less white fat, 30% lower cholesterol, and no change in food intake

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