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Changes in the BBB associated with Alzheimer's disease primarily include endothelial abnormalities such as reactive gliosis, mitochondrial damage, alterations in the extracellular matrix, disrupted tight junctions, and both molecular and functional changes in astrocytes

Ferulic acid-based polymer nanoparticles, which were biodegradable, may release ferulic acid sustainably and tunablely to inhibit macrophage foam cell production

Introduction: Direct vs Indirect IGF-1 Pathway Activation Two fundamentally distinct approaches to IGF-1 pathway research have emerged: direct exogenous IGF-1 administration (IGF-1 LR3) and indirect stimulation through growth hormone (HGH), which promotes hepatic IGF-1 synthesis

CJC-1295 DAC is a long-acting growth hormone-releasing hormone (GHRH) analog that stimulates the pituitary gland to increase growth hormone (GH) and IGF-1 levels