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Soy proteins appear to bind initially to the coffee compounds in the small intestine, but then our good bacteria can release them so they can be absorbed in the lower intestine

Figure 1 Raw reads were processed with Trimmomatic ( Rattus norvegicus reference genome (release 94) using the software Spliced Transcripts Alignment to a Reference (STAR) ( P values lower than 0.01 were considered differentially expressed (DEG) and were displayed in an UpSetPlot using the UpSetR R package ( 2.4 Validation of selected DEG by RT-qPCR The High-Capacity cDNA Reverse Transcription Kit (Thermo Fisher) was used to synthesize cDNA following the manufacturers protocol

Additional information Peer review information Nature Immunology thanks Marcus Conrad, Christian Lood and Chandra Mohan for their contribution to the peer review of this work