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careful riskbenefit assessment is warranted Those with pre-existing gallbladder disease : Rapid weight loss can precipitate gallstone formation or worsen existing biliary conditions People with severe gastrointestinal disease, including gastroparesis : GLP-1 receptor agonists slow gastric emptying, which may worsen symptoms in those with pre-existing gastric motility disorders Older adults : Age-related changes in renal and hepatic function may affect drug metabolism and increase sensitivity to side effects

Compared to the 25% of subjects with the lowest plasma TMAO levels at baseline, the 25% with the most TMAO in their blood were 2-3 times more likely to suffer a nonfatal heart attack, a stroke, or a fatal CVD event

Wang N, Yang J, Chen R, Liu Y, Liu S, Pan Y, et al

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