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If your body develops anti-drug antibodies against tirzepatide, the medication may become less effective even when you switch to a fresh supply

For example, someone with cardiovascular symptoms wouldnt meet the criteria unless they also had gastrointestinal or dermatological symptoms.[ref] One form of MCAS, now called idiopathic anaphylaxis , involves sudden, often random-seeming episodes of throat swelling, itching, wheezing, shortness of breath, stomach pain, nausea, vomiting, diarrhea, and a drop in blood pressure

This includes older adults, individuals with digestive disorders, and those who have undergone weight loss surgery