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Meanwhile, the neurotransmitters gamma-aminobutyric acid (GABA) and glutamate participate in Ca 2+ signaling at postsynaptic neurons [93, 94]

11 , 12 , 13 , 14 , 15 Prooxidant activity is the main mechanism determined for the anticancer activity of vitamin C and acts on redox imbalance in a dosedependent manner

These data, together with mechanistic work showing that insulin stimulates VEGF and IGF production while glucose primes macrophages for inflammatory cytokine release 394 , suggest that the combination of high glucose and high insulin is more deleterious than hyperglycemia alone