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Increased body fat in the upper chest and obliques Abdominal weight gain Lethargy/fatigue Brain fog Mood swings Irritability Low libido Depression Anxiety Long term, excess estrogen in men can trigger abnormal cell growth and prostate enlargement

The NILs were confirmed to have a genetic background from Enrei through resequencing (Supplementary Fig

The results of the correlation analysis were visualized using a chord diagram (Figure 6) and compounds belonging to the classes of amino acid, lipid, and carbohydrate were the most enriched in the changed endogenous metabolites

The research was funded by the Howard Hughes Medical Institute, the National Institutes of Health, the Biotechnology and Biological Sciences Research Council with AstraZeneca, the Engineering and Physical Sciences Research Council UK Catalysis Hub, the EU Horizon 2020 Programme under the Marie Sklodowska-Curie program, the Felix Foundation and the Engineering and Physical Sciences Research Council with Pfizer.
