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Cysteine-derived H 2 S in cancer development A role for cysteine in cancer associated with disturbed metabolism and signalling of H 2 S, per-sulphides and poly-sulphides has been established on the basis of a range of evidence

Studies have reported that in patients with severe IUA, the recurrence rate can reach up to 62.5% after surgery, primarily due to persistent fibrosis and insufficient angiogenesis during endometrial repair

Regulatory role on signal transduction Omega-3 PUFAs can act as agonist ligands for G protein-coupled receptor 40 (GPR40) and G protein-coupled receptor 120 (GPR120), peroxisome proliferator-activated receptors (PPARs) and retinoid X receptor (RXRA)

Case Example: The High-Functioning, High-Serotonin Anxious Type Patient: 35-year-old female executive History of OCD, social anxiety Racing mind, agitation, gut pain, poor sleep Over-reactive to SSRIs, B vitamins, and magnesium glycinate Genetics: MAOA TT (slow) COMT slow MTHFR + DHFR polymorphisms Treatment: B2 (FAD) and NAC to gently support serotonin clearance Magnesium taurate (instead of glycinate) Antioxidants and anti-inflammatories Niacin + taurine to support neurotransmitter modulation Gut repair and low-histamine, anti-inflammatory diet Results: OCD symptoms diminished within 4 weeks, anxiety dropped significantly, and sleep stabilised without medication