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Biomolecules 15(9):1284

doi: 10.1158/0008-5472.CAN-10-0740

Gu X, Zhang S, Ma W, Wang Q, Li Y, Xia C, et al

Despite the increased polar character, these THC metabolites are not themselves sufficiently hydrophilic for normal bodily excretion and likely also utilize protein-mediated shuttling to reach their respective intracellular metabolic enzymes
