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suggested that LSCs were uniquely dependent on amino acids that catabolize into the intermediates of the TCA to fuel OXPHOS in de novo AML patients

Systems biology and new technologies enable predictive and preventative medicine

Diabetes Care 27:21782183 Ziegler D, Low P, Litchy W, Boulton AJ, Vinik AI, Freeman R, Samigullin R, Tritschler H, Munzel U, Maus J, Schtte K, Dyck PJ (2011) Efficacy and safety of antioxidant treatment with -lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial

This understanding has stimulated the development of copper-based therapeutic strategies, including copper ionophores, chelators, and complexes, aimed at exploiting the vulnerability of cancer cells to copper-induced cytotoxicity