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10.1038/s41419-021-03718-4 227 WangQ.GuoY.WangW.LiuB.YangG.XuZ.et al (2021b)
Simultaneously, BPC-157 modulates the nitric oxide (NO) system bidirectionallyincreasing NO in deficiency states and decreasing it in excesswhich is critical for vascular tone and inflammation resolution at injury sites

PMID: 39891996, PMCID: PMC11840234, DOI: 10.1016/j.ebiom.2025.105578

Thus, the cellular ratio of NADPH to NADP + has cascade effects on the ability of the glutathione pathway to act as a defense against oxidative stress in a cell
