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Truzzi E., Nascimento T

Since peptides usually arent well-absorbed in the digestive system, their effects are often limited when taken orally, It is important to note that the same may apply to BPC-157 and it may only have local effects on the stomach when taken orally

and CurNisNp with 3-month stability, while the remaining studies omit or provide insufficient stability profiles

Thanks to their expanded interface with the target protein, peptide PROTACs demonstrate superior potency, higher selectivity, and reduced toxicity compared to low molecular weight compounds, especially when targeting proteins lacking well-defined binding pockets (Kargbo, 2019)