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Instead, the diagnosis must align with the medical purpose of the drug administered

Its overexpression is associated with a decrease in acquisition of MET, cyclin D1, and CDK4 (oncogene and cell cycle-related proteins), which eventually lead to are duction in cell growth and enhanced cell apoptosis in vitro and in vivo (Jiang et al., 2016)

9 Approval of sorafenib (multi-kinase inhibitor of vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and Raf kinases) was the first systemic therapy to conclusively demonstrate an improvement in overall survival in patients with advanced HCC

Rasmussen et al