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In situations when the emergency provider is not X-waivered and next day follow-up cannot be guaranteed, the patient can be directed to return to the ED for subsequent doses of buprenorphine (up to 72 hours after initial presentation) until outpatient follow-up and long term MOUD can be established

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Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the gold standard for quantifying dihexa in plasma, with a lower limit of quantification typically around 15 ng/mL depending on sample preparation and ionization efficiency
