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Molecular targets and pathways involved in liver metastasis of colorectal cancer

doi: 10.1016/j.freeradbiomed.2018.02.009 112 WillisBCLieblerJMLuby-PhelpsKNicholsonAGCrandallEDDu BoisRMet al

The activity of endogenous antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase is enhanced by curcumin, playing a crucial role in detoxifying reactive oxygen species and maintaining cellular redox homeostasis (Santana-Martnez et al., 2019)

These systems include a) enzymatic defences such as catalase, superoxide dismutase and glutathione that inhibit the formation of toxic OH - by metabolizing superoxide, H 2 O 2 and lipid peroxides, and b) entrapping free radical defences such as histidine-peptides, the iron-binding proteins transferring and ferritin, dihydrolipoic acid, reduced CoQ 10 , melatonin, urate and plasma protein thiols [24, 191-193]