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Description
Seven out of 20 studies reported an overall high risk of bias, due to bias from the randomization process, bias due to missing outcome data, bias in measurement of the outcome, and bias in selection of the reported result

R and R are attached to the same nitrogen atom, they can be combined with the nitrogen atom to form a 4-, 5-, 6-, or 7-membered ring

These doses are approximately 5 and 6 times the recommended human total daily dose on a body surface area basis

It received GRAS (Generally Recognized as Safe) status from the FDA as a food ingredient in 2011
