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Small amounts of uncoordinated and redox-active Fe 2+ form the labile iron pool in cells and lysosomes recycle endogenous iron sources like ferritin and mitochondria, thus lysosome is also a particularly large liable iron pool [149, 150]

Abstract Background Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental condition in which pharmacological and microbiota-targeted interventions are emerging as promising therapeutic avenues

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In addition, the degradation of intracellular GPX4 through CMA pathways can lead to the accumulation of intracellular phospholipid peroxide and ferroptosis, and host cells usually use GPX4 for peroxide phospholipids reduction, thus protecting cells from death