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40 KatagiriS.ShibaT.ToharaH.YamaguchiK.HaraK.NakagawaK.et al (2019)
The differences come down to duration and technology
This signal was also identified in MDCK cells, an immortalized kidney cell line, as a required motif for targeting of ATP7A to the basolateral membrane
The compounds low oral bioavailability and limited ability to cross the blood-brain barrier are challenges that still need to be addressed
