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Consistently, oral administration of a CutC/D inhibitor markedly reduced plasma TMAO levels and rescued diet-induced platelet hyperreactivity and thrombosis without significant toxicity or increased bleeding risk (Roberts et al., 2018)

These findings highlight the important role of the carnitine pool as a bridge between cellular metabolism and epigenetic regulation and open the possibility of developing novel therapeutic strategies targeting specific metabolic and epigenetic targets

Bioorg Med Chem

After 12 weeks of twice-daily application over the entire face, evaluation by visiometry revealed a significant reduction in two skin-roughness parameters (R2 and R3) among the women in the L-carnitine group, reflecting a visible improvement in skin texture and a decrease in wrinkles compared with the placebo