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Pegylation alone does not allow nanoparticles to cross the BBB, as it has been shown in multiple studies [87,123,145,146]

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Proline suppresses rubisco activity by dissociating small subunits from holoenzyme

demonstrates that STAT3 binds to consensus DNA response elements in the promoters of the GPX4, SLC7A11, and regulates their expression, thereby establishing a negative STAT3-ferroptosis regulatory axis in gastric cancer (Ouyang et al., 2022)
