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Under physiological conditions, triiodothyronine (T3) maintains mitochondrial integrity by inducing PGC1-, Nrf1/Nrf2, and TFAM to stimulate mitochondrial biogenesis and fatty acid oxidation, while also activating AMPK signaling via integrin v3 (84, 85)

Role of Carnitine in the Pathogenesis of NAFLD and Associated Diseases Carnitine and Multiple Hit Hypothesis in the Pathogenesis of NAFLD The prevalence of NAFLD is increasing at a tremendous rate, currently affecting about 24% of the world's population

The consistent downregulation of TCA intermediates following MA exposure in both the current and previous studies suggests that both initial MA exposure and subsequent re-exposure may lead to increased energy consumption

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