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Silence or correct mutations: e.g., SNCA and LRRK2 via RNA interference (RNAi) or CRISPR-Cas9 ( AAV2-based vectors have been used in clinical trials to deliver therapeutic genes to the striatum or SNpc, showing safety and moderate benefit ( 5.5 Stem cell-based approaches Stem cell therapies offer the potential to replace lost dopaminergic neurons and restore neural circuitry
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These findings demonstrate that alterations in GSTM1 KD astrocyte responses to acute brain inflammation negatively impact neuronal activities and increase their cellular stress in a non-cell autonomous manner in vivo
