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TSH then acts on the thyroid gland to promote the synthesis and secretion of T4 and T3, with T3 being the metabolically active form

N., Aldous, C., Kruger, H

It should be noted, however, that ALDH1A1, but not CYP2E1, is a downstream target of NRF2, which was found to be activated in untreated GCLM KO mouse liver

Mild to moderate fat loss