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Three of the 5 patients experienced increases in both serum tHcy and serum MMA, which were reduced significantly upon vitamin B-12 administration (46)
On one side, this signaling axis could explain the beneficial effects mediated by exercise and caloric restriction in young mice and, on the other side, it could represent a target for determining the adaptive response of skeletal muscle under aging or pathological conditions
[DOI] [PMC free article] [PubMed] [Google Scholar] 106.Eisele P.S., Furrer R., Beer M., Handschin C
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