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E.ElfoulyY.HaniY.HegazyY.et al

Glutathione catalytically detoxifies: hydroperoxides, peroxynitrites, and lipid peroxides.11 Another way glutathione protects cells from oxidants is through recycling of vitamins C and E as shown in Figure 4.10 Another indication of the key roles of glutathione in health is that the accumulation of GSSG due to oxidative stress is directly toxic to cells, inducing apoptosis by activation of the SAPK/MAPK pathway.12 Glutathione depletion triggers apoptosis, although it is unclear whether it is mitochondrial or cytosol pools of GSH that are the determining factor.13 Perhaps the best indicator of the importance of glutathione is that its cellular and mitochondrial levels directly are highly associated with health and longevity

Nrf1 is required for basal expression of GS in the mouse (Kwong et al., 1999) and Nrf1 and Nrf2 overexpression induced the human GS promoter activity (Lee et al., 2005)