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In reports published by Kapoor [21], Bahi-Buisson [18], Raizen [19], and Diao [22], all children with the p.S445L mutations (6 cases in total) developed generalized tonic-clonic seizures between the first week and fifth month after birth [23]
Such reactions will subtract RNS from critical cellular targets, such as cell membrane lipids and proteins belonging to the complexes of the electron transport chain, thereby explaining why GSH status appears to be so critical in modulating the susceptibility to NO
(PubMed) Banerjee S, Hawksby C, Miller S, Dahill S, Beattie AD, McColl KE
& Kumolosasi, E
