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Notably, several uremic solutes have also been implicated in systemic endothelial dysfunction and microvascular injury, suggesting a link to the proteinuriarelated cerebrovascular changes observed in epidemiological PD studies [145]

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10.1038/cr.2016.95 36 GeC.HuangM

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475 Based on data from the Chicago Health and Aging Project, in 2020 an estimated 700,000 people age 65 and older in the United States had Alzheimer's dementia at death

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