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Nature Structural Biology, 4(7), 578585
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[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Yang W.H., Qiu Y., Stamatatos O., Janowitz T., Lukey M.J
In individuals with T2DM, chronic hyperglycemia is known to downregulate GIPR expression and impair GIP-stimulated insulinotropic activity, thereby limiting the efficacy of GIP monotherapy [21]
