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To that end, we systematically reviewed cartilage repair clinical trials to identify common exclusion criteria and reviewed the literature to identify emerging regenerative approaches that are poised to overcome these current exclusion criteria
Laboratory studies reveal TB-500 reduces production of inflammatory mediators including TNF- and IL-1 by 55% while enhancing anti-inflammatory IL-10 and TGF- expression, creating balanced immune responses that clear damaged tissue while supporting regeneration
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