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Vitamin B12 deficiency is believed to be one of the most common nutrient deficiencies in the world, especially among people taking stomach acid-altering medications and antibiotics frequently, along with the elderly and sometimes vegetarians/vegans

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Simultaneously, the preservation of SAM levels maintains cellular capacity for critical methylation reactions including histone modifications, DNA methylation, and protein methylation that regulate gene expression and protein function

As a result, it is being investigated as a potential tool for studying human fat metabolism and for developing anti-obesity drugs
