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GLUTATHIONE : Found in every cell of the human body, Glutathione plays important roles in antioxidant defense, detoxification, and regulation of cellular metabolism

This mechanism offers a novel pathological perspective on the role of copper in neurodegenerative disorders

This distinction raises the possibility that declining renal GPX4 content and increasing urine GPX4 levels may represent different facets of the same pathological process, namely that GPX4 depletion from tubular cells is accompanied by its leakage or shedding into urine during oxidative or ferroptotic injury