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Description
Preclinical studies in rodents have shown an association between GLP-1 receptor activation and thyroid C-cell changes, although a direct causal link in humans has not been established, and UK/EU SmPCs for authorised GLP-1 RAs do not list MTC or MEN2 as a formal contraindication
Free Radic Res
doi: 10.7759/cureus.28218
Integrating toxicokinetic data, mechanistic evidence, and exposure science therefore provides a more reliable framework for evaluating risks and distinguishing genuine causal relationships from statistical correlations arising from bias, co-exposures, or measurement limitations
