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- Active cancer

In physiological wound healing, the temporary upregulation of TGF- induces NR4A1 expression creating a negative feedback loop, while the persistent activation of TGF- signalling in fibrotic diseases uses protein kinase B (PKB), also known as AKT, and histone deacetylase-dependent mechanisms to inhibit NR4A1 expression and activation [17]

International Journal of Immunopharmacology, 1997

Mine haven't come yet, but I still have my old ones to use up first
