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An umbrella meta-analysis published in Clinical Therapeutics in 2023, which analyzed 11 prior meta-analyses of randomized controlled trials, confirmed that berberine supplementation was effective in reducing fasting blood glucose, HbA1c, HOMA-IR (a marker of insulin resistance), fasting insulin levels, and inflammatory biomarkers including CRP, TNF-alpha, and IL-6

However, researchers have identified several indirect mechanisms through which BPC-157 could theoretically support the conditions necessary for healthy testosterone production: The Bottom Line BPC-157 supports the biological systems that keep testosterone production healthy vascular integrity, inflammation control, tissue repair, and potentially gut-brain-gonad signaling