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resistance) (Tan, Pennell, et al., 2023)

Stimulation with lipopolysaccharide (LPS) and IFN not only activated M0 macrophages into M1 phenotype but also upregulated the expression of inducible nitric oxide synthase (iNOS) in Gpx4-deficient macrophages

For example, miR-324-3p, miR-4443, miR-302a-3p, miR-27a-3p, and miR-186-5p are connected to crucial antioxidant and iron-transport mechanisms, while specific lncRNAs (e.g., LINC00336, ITGB2-AS1, LINC00597) and circRNAs (circDTL, circPDSS1) function through unique miRNAmRNA interactions

Over time, the HPA axis rebalances, cortisol rhythms normalise, and anxiety scores measurably decline