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Quantification of the synergy using multidimensional synergy of combinations (MuSyC) 37 technique for AXT050 and sorafenib at steady state suggest an inconsequential synergistic efficacy ( obs = 0.001 and 0.035 for pAkt and pERK, respectively), as well as a negligible antagonistic potency (log( 2 ) = 0.02 and 0.05 for pAkt and pERK, respectively)

These improvements were linked to increased serotonin and dopamine levels and reduced corticosterone concentrations, which are commonly elevated in stress-related disorders [234]

Gene conversions in the growth hormone gene family of primates: stronger homogenizing effects in the Hominidae lineage

Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease