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118,119,120,121 In addition, it has been observed that naive T cells from older individuals exhibit reduced responsiveness to the superantigen toxic shock syndrome toxin-1 compared to younger individuals, 122,123 which may be caused by low dual specificity phosphatase 6 levels in naive T cells, resulting in a rise in the threshold of TCR activation

At the genomic level, Epitalon modulated the expression of key circadian rhythm genes: Clock expression in leukocytes decreased 1.8-fold, Cry2 expression doubled, and Csnk1e expression in lymphocytes decreased by 2.1-fold, all with statistical significance

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We found significant elevation of ferroptosis features in both types of lung pathologies in patient autopsies