nrf2 glutathione peroxidase NRF2, a Superstar of Ferroptosis Roles of Oxidative Stress and

a large portion of the marketed drugs for the treatment of neurological disorders are in fact directed against targets outside the brain (e.g., cerebral vasculature, or immune system)

For patients with unexplained mental and motor developmental delay, seizures, recurrent acute encephalopathy, and systemic multisystem manifestations, it is important to conduct early diagnostic investigations such as cranial MRI, EEG, plasma amino acid metabolism, urine organic acid metabolism analysis, CSF metabolism, and genetic testing to clarify the diagnosis

Our bodies naturally produce glutathione, a powerful antioxidant

4.4 Obesity-induced gut microbiota dysbiosis and OS Through extensive studies, it has been demonstrated that obesity markedly changes the composition of microbiota (39), characterized by decreased diversity of microbiota compared with that in normal-weight individuals (40)