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Description
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Its main product, ADPR, can either be metabolized by the CD203a/CD73 exoenzymatic tandem into ADO (40), which binds to purinergic type 1 (P1) receptors (particularly A2A and A2B), or facilitate Ca2+ influx through TRPM2 channels (45)
Therefore, it is apparent that CD169 macrophages, like Trojan horse, facilitate viral transmission, excessive inflammation, and activation-induced lymphocyte death [114]
