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then, protein C atoms and heavy atoms of AdoCbl/OHCbl and Cobalt were restrained to minimise/equilibrate (2 ns) main chain of protein
10.1038/nchembio.2418

2010;299(1):H193201
Overexpression of COX2 results in increased production of prostaglandin 2 (PGE2), which leads to subsequent signaling through the MAPK, Src and Akt pathways, as well as VEGF and HIF-1 [201]