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112 More recently, it was suggested that methotrexate causes ferroptosis through activation of autophagy, leading to increased degradation of ferritin and liberation of ferrous iron (ferritinophagy), which promotes LPO and liver injury

Topical applications are used primarily for skin benefits but may not significantly affect overall glutathione levels

26 In addition, the activity of the cytochrome P450 reductase (POR) also requires NADPH, which has a major role in the metabolism of drugs, xenobiotics, and steroid hormones

The NADPH Oxidase and Microbial Killing by Neutrophils, With a Particular Emphasis on the Proposed Antimicrobial Role of Myeloperoxidase within the Phagocytic Vacuole