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Description
If the stress continues and even grows more severe, a breakdown in the functioning of these two systems can occur
J.StanderM
10.1080/13880209.2018.1557698 Pharm Biol
This reaction, when it occurs in the cytosol, is catalyzed by methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), a trifunctional enzyme with 10-formyl-THF synthase, 5,10-MTHF dehydrogenase, and 5,10-MTHF cyclohydrolase activities, with reduction of the nicotinamide adenine dinucleotide phosphate oxidized form (NADP + )
