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Importantly, tumors with LOH have lower measurable GPx-1 enzyme activity and increased accumulation of 8-hydroxydeoxyguanosine, a pro-mutagenic DNA-oxidation product, suggesting that LOH results in oxidative stress in these tumors

Superoxide dismutases in gastric and esophageal cancer and the prognostic impact in gastric cancer

The combination is used within studies to investigate both local and systemic repair simultaneously

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