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Glycerol phenylbutyrate (GPB) is a medication approved by the Food and Drug Administration in 2013 for the treatment of patients with urea cycle disorders or innate metabolism errors that manifest as hyperammonemia, whose effect was emulated in the cirrhotic population.49 GPB is hydrolyzed by pancreatic lipases for producing glycerol and 3 molecules of phenylbutyric acid

Future investigations on RDD aim to further elucidate its underlying pathways and enhance its clinical applications

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Specifically, patients with CGL1 and CGL2 do not have either of these tissues (434, 455)