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Protraction of this process then results in chronic lung inflammation as well as lung fibrosis as pro-inflammatory cytokines such as IL-1, IL-18, and TNF enhance the recruitment and proliferation of fibroblasts and mesenchymal cells to produce fibroblastic foci and to generate components of the extracellular matrix including collagen, leading to fibrotic scarring of the lung tissue [180]

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doi:10.1016/j.bbr.2011.11.027 Fink JS, Smith GP (1980) Mesolimbicocortical dopamine terminal fields are necessary for normal locomotor and investigatory exploration in rats