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Description
Biochem Pharmacol 1966;15(10):15231535
Vpr induces oxidative stress by stabilizing p53 protein, increasing transforming growth factor-beta protein levels and ROS production, and suppressing antioxidant enzymes 118,119,120
Only free glutathione bound to NEM, as NEM has no reducing activity
Conclusions This study demonstrated that proline supplementation in GalN-induced liver failure model significantly activated ROS-eliminating system such as catalase and glutathione system in the liver within 24 hours after GalN administration
