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This tiny complex is naturally present in human plasma, saliva and urine, and its levels tend to decline with age

Filter all solutions through 0.22 m membranes before measurement

The authors wish to thank Dr Michael Braden and UM's Molecular Core Computational Facility for assistance with the structural modelling, as well as Drs John Gerdes, Michael Kavanaugh and Charles Thompson for their valued discussion

124 Additionally, in a small study of 244 patients with coronary artery disease and obstructive sleep apnea, a significant reduction in cardiovascular events was found when adjusting for adherence, suggesting increased use of CPAP may confer better cardiovascular benefits