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SARS-CoV-2 has been shown to decrease GSH by reducing Cys uptake, increasing thiol efflux, inhibiting Nrf2, and inhibiting BRCA1

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Furthermore, FXR transcriptionally activates Acsl4 in intestinal epithelial cells (IECs), promoting ferroptosis and subsequently impairing ILC3 function, and can induce Wnt2b in cancer-associated fibroblasts (CAFs) within the tumor stroma, fostering a pro-tumorigenic niche (92, 93)