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This led to a reduction in MMR coverage in the UK and large-scale outbreaks, with a return to endemicity of the disease as the virus circulated, finding susceptible children who had not been not immunized and causing disease even among adequately immunized children

Conversely insomnia leads to activation of the immune system which causes pathological changes in nerve cells such as inflammation and apoptosis, in which the production of inflammatory mediators disrupts the delicate balance required for neurophysiological action and adversely affects memory, neuroplasticity and neurogenesis [50], which interact with each other

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