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Examples of ototoxic cytostatic agents Methotrexate : Associated with temporary or permanent SHL in some patients, likely due to its interference with folate metabolism and resultant neurotoxicity

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To confirm that the gut microbes were indeed major regulators of weight gain in the smoking cessation mice, the researchers collected microbiomes from smoking or smoking-cessation mice at various timepoints, and transferred these into germ-free mice that had never been exposed to cigarette smoke

Recent Results Cancer Res